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Santha Santhirodaya mathirai induced changes
in liver enzyme levein liver disorder patients
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M. Krishnaveni*
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T. Prema**
Siddha system of medicine:
This is the first system to emphasize health
as the perfect state of physical, psychological, social and
spiritual components of a human being. The fundamental principle
of this medicine successfully eliminates the evil side effects
without losing the beneficial medicinal properties.
Siddha system of medicine is being greatly
recognized as a definite approach to liver disease treatment.
Large numbers of medicines are available for liver disorders
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Liver is the largest organ in the human
body, plays a vital role in many physiological processes.
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According to Siddha liver is the seat of
Pitta.
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Pitta humor is involved in liver
disorders.
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Aggravation of pitta causes liver diseases
such as fatty liver, cirrhosis, and hepatitis.
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The signs and symptoms of Cirrhosis
similate the symptoms described in Azhal kalleeral noi in
Siddha.
PATHOGENESIS
Excessive bile production or obstruction
in the flow of bile usually indicates high pitta, which in turn
affects the agni or enzyme activities responsible for
absorption, digestion and metabolism.
Pitta can be aggravated by many factors of
diet and lifestyle. They include alcohol abuse, eating red meat,
eating too much spicy or oily, heavy foods, lack of sleep, too
much direct exposure to the sun and smoking. When pitta becomes
aggravated it results in liver diseases such as Kamalai and
Kalleeral noi.
Clinical evaluation:
AZHAL KALEERAL NOI Signs and Symptoms
:
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Anorexia
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Nausea
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Vomiting
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Fever
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Jaundice
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Edema
Diagnostic criteria:
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The magnitude of pitta aggravation is
diagnosed through pulse reading, observing the conjunctiva,
tongue, and palpation of the abdomen.
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Using Modern biochemical parameters such
as Serum bilirubin, S.G.O.T., S.G.P.T., Serum alkaline
phosphatase.
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Venkaram |
Rasa Karpooram |
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Preparation of the drug
Ingredients:
Venkaram (Borax) – 10gm.
Rasa Karpooram – (Mercuric sub
chloride) – 20 gm.
Manjal (Curcuma longa) – 60gm.
Elumichai Charu (Lemon Juice) – 110
gm.
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Manjal |
Method
Purified Rasa Karpooram, Purified
Venkaram and manjal were ground with lime juice for 12 hrs, then
brought into fine consistency, rolled into 100mg pills and dried
in shade.
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Santha Sandhirodaya Mathirai |
Therapeutic properties
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Rasa karpooram (Mercuric subchloride) is
useful for pitta thodam, jurm,kamalai,etc.
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Mercury, is widely used in Siddha
medicine. Siddhars used Mercury not only to cure innumerable
diseases, but also to rejuvenate the body and promote longevity.
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Manjal (Curcuma longa) is useful for many
diseases.It has potent hepatoprotective property also.
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Vengaram(Borax) is effective in peptic
ulcer, skin diseases etc.
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Lowering of bio chemical parameters were
observed in ccl4 induced damaged liver in rat .(Journal of
research in Ayurveda and Siddha Jan-June 1995 vol.XVI o.1-2).
Atomic absorption spectrometry analysis
Acute toxicity study
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Swiss albino mice of either sex weighing
between 20-25 gms were divided into ten groups of six animals
each.
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Santha santhirodaya mathirai was prepared
as fine suspensions in honey.
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Group I to IX were administered with
various doses of 100, 200, 500, 1000, 2000, 5000, 7000, 10,000
mg of Santha santhirodaya mathirai /kg body weight.
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Group X received the vehicle honey
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After adminstration behavioural changes
and mortality symptoms were observed continuously for the first
12 hours, then 24 hours, 48 hours and 72 hours.
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Mortality and toxic symptoms were
recorded.
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No mortality was observed upto 5000 mg/kg
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33.33% mortality observed at 6000 mg/kg
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50% mortality observed at 7000 mg/kg
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100% mortality at 10000 mg/kg body weight.
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Hence the LD50 of S.S.Pills is 7000 mg/kg
Clinical study
Selection of patients:
Experimental design:
Group I: Disease free healthy individual
(n=10)
Group II: Patients with Azhal kalleeral
noi on treatment with S.S.Pills 3 pills twice with honey a day
for a period of 48 days.(n=20)
Results and discussion
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The concentration of mercury present in
the sample used is 6.204mg/dl
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The acute toxicity study shows that the
LD50 is 7000mg/kg body weight.
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Lowering of bio chemical parameters were
observed in ccl4 induced damaged liver in rat .(Journal of
research in Ayurveda and Siddha Jan-June 1995 vol. XVI o.1-2 )
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Clinical and biochemical changes were
observed in majority of patients.
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Anorexia, nausea, vomiting, fever were
improved within a week.
Effect of s.s.pills on serum enzyme levels
in azhal kalleeral noi patients
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Normal |
Group I |
Group II |
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Bilirubin |
0.8 |
2.8 |
0.9 |
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S.G.O.T |
42 |
141.3 |
67.2 |
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S.G.P.T |
14.5 |
55.1 |
18.2 |
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Alka.
Phosphatase |
13.6 |
50.5 |
14.25 |
Effect of s.s.pills on serum enzyme levels
in azhal kalleeral noi patients
Summary and conclusion
Based on the above investigation, it can be
concluded that Santha santhirodaya pill has got the curative
potential to reduce the aggravated pitta which can be evidenced
from the pronounced biochemical changes observed. No side effects
were observed which suggests that the drug is safe to use
therapeutically. This kind of finding can be exploited in the
successful treatment of Azhal kaleeral noi with Santha
santhirodaya mathirai.
Acknowledgement
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Principal, Government Siddha medical
college, Chennai 106
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Dr. G.Veluchamy former Director, Central
Research Institute, Chennai 106.
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Dr. Sasikala Ethirajulu, Research officer,
Central Research Institute, Chennai 106.
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Mr. Anantharaman, Central research
Institute, Chennai 106.
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Dr. V. Muthulakshmi M.D(siddha) Ph.d
,Quality Controller, Tampcol, Chennai
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Dr. Habeeb M.D (Unani) Govt. Unani medical
college, Chennai
* Asst. Lecturer,
Govt. Siddha Medical College, Chennai, India.
** Professor, TAMIL
UNIVERSITY, Thanjavur, Tamilnadu, India.
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